MS-DOS 6.22 does not include universal CD-ROM drivers by default. You will need to add OAKCDROM.SYS to your CONFIG.SYS and MSCDEX.EXE to your AUTOEXEC.BAT .
: Many community ISOs come pre-loaded with essential drivers, such as OAKCDROM.SYS , which allows MS-DOS to recognize CD-ROM drives—a feature not natively included in the base setup. download ms dos 6.22 bootable iso
You're looking for a way to download a bootable ISO image of MS-DOS 6.22. Here's some information and guidance: MS-DOS 6